Diacepan
Brand names,
Diacepan
Analogs
Diacepan
Brand Names Mixture
Diacepan
Chemical_Formula
C16H13ClN2O
Diacepan
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Diacepan
fda sheet
Diacepan
msds (material safety sheet)
Diacepan
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Diacepan
Molecular Weight
284.74 g/mol
Diacepan
Melting Point
125-126oC
Diacepan
H2O Solubility
Slightly soluble (50 mg/L)
Diacepan
State
solid
Diacepan
LogP
2.988
Diacepan
Dosage Forms
Tablets; Injectable solution
Diacepan
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Diacepan
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Diacepan
Absorption
Essentially complete, with a bioavailability of 93%.
Diacepan
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Diacepan
Patient Information
Diacepan
Organisms Affected
Humans and other mammals