Valaxona
Brand names,
Valaxona
Analogs
Valaxona
Brand Names Mixture
Valaxona
Chemical_Formula
C16H13ClN2O
Valaxona
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Valaxona
fda sheet
Valaxona
msds (material safety sheet)
Valaxona
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Valaxona
Molecular Weight
284.74 g/mol
Valaxona
Melting Point
125-126oC
Valaxona
H2O Solubility
Slightly soluble (50 mg/L)
Valaxona
State
solid
Valaxona
LogP
2.988
Valaxona
Dosage Forms
Tablets; Injectable solution
Valaxona
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Valaxona
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Valaxona
Absorption
Essentially complete, with a bioavailability of 93%.
Valaxona
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Valaxona
Patient Information
Valaxona
Organisms Affected
Humans and other mammals