Ansiolisina
Brand names,
Ansiolisina
Analogs
Ansiolisina
Brand Names Mixture
Ansiolisina
Chemical_Formula
C16H13ClN2O
Ansiolisina
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Ansiolisina
fda sheet
Ansiolisina
msds (material safety sheet)
Ansiolisina
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Ansiolisina
Molecular Weight
284.74 g/mol
Ansiolisina
Melting Point
125-126oC
Ansiolisina
H2O Solubility
Slightly soluble (50 mg/L)
Ansiolisina
State
solid
Ansiolisina
LogP
2.988
Ansiolisina
Dosage Forms
Tablets; Injectable solution
Ansiolisina
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Ansiolisina
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Ansiolisina
Absorption
Essentially complete, with a bioavailability of 93%.
Ansiolisina
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Ansiolisina
Patient Information
Ansiolisina
Organisms Affected
Humans and other mammals