Valiquid
Brand names,
Valiquid
Analogs
Valiquid
Brand Names Mixture
Valiquid
Chemical_Formula
C16H13ClN2O
Valiquid
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Valiquid
fda sheet
Valiquid
msds (material safety sheet)
Valiquid
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Valiquid
Molecular Weight
284.74 g/mol
Valiquid
Melting Point
125-126oC
Valiquid
H2O Solubility
Slightly soluble (50 mg/L)
Valiquid
State
solid
Valiquid
LogP
2.988
Valiquid
Dosage Forms
Tablets; Injectable solution
Valiquid
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Valiquid
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Valiquid
Absorption
Essentially complete, with a bioavailability of 93%.
Valiquid
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Valiquid
Patient Information
Valiquid
Organisms Affected
Humans and other mammals