Bialzepam
Brand names,
Bialzepam
Analogs
Bialzepam
Brand Names Mixture
Bialzepam
Chemical_Formula
C16H13ClN2O
Bialzepam
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Bialzepam
fda sheet
Bialzepam
msds (material safety sheet)
Bialzepam
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Bialzepam
Molecular Weight
284.74 g/mol
Bialzepam
Melting Point
125-126oC
Bialzepam
H2O Solubility
Slightly soluble (50 mg/L)
Bialzepam
State
solid
Bialzepam
LogP
2.988
Bialzepam
Dosage Forms
Tablets; Injectable solution
Bialzepam
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Bialzepam
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Bialzepam
Absorption
Essentially complete, with a bioavailability of 93%.
Bialzepam
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Bialzepam
Patient Information
Bialzepam
Organisms Affected
Humans and other mammals