Tranquirit
Brand names,
Tranquirit
Analogs
Tranquirit
Brand Names Mixture
Tranquirit
Chemical_Formula
C16H13ClN2O
Tranquirit
RX_link
http://www.rxlist.com/cgi/generic/diazepam.htm
Tranquirit
fda sheet
Tranquirit
msds (material safety sheet)
Tranquirit
Synthesis Reference
Reeder, Sternbach; U.S. Pat. 3,371,085 (1968)
Tranquirit
Molecular Weight
284.74 g/mol
Tranquirit
Melting Point
125-126oC
Tranquirit
H2O Solubility
Slightly soluble (50 mg/L)
Tranquirit
State
solid
Tranquirit
LogP
2.988
Tranquirit
Dosage Forms
Tablets; Injectable solution
Tranquirit
Indication
Used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome.
Tranquirit
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Tranquirit
Absorption
Essentially complete, with a bioavailability of 93%.
Tranquirit
side effects and Toxicity
Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Tranquirit
Patient Information
Tranquirit
Organisms Affected
Humans and other mammals