Etimonis
Brand names,
Etimonis
Analogs
Etimonis
Brand Names Mixture
Etimonis
Chemical_Formula
C6H9NO6
Etimonis
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Etimonis
fda sheet
Etimonis
msds (material safety sheet)
Etimonis
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Etimonis
Molecular Weight
191.139 g/mol
Etimonis
Melting Point
88-91oC
Etimonis
H2O Solubility
1.07E+005 mg/L
Etimonis
State
Solid
Etimonis
LogP
-0.15
Etimonis
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Etimonis
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Etimonis
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Etimonis
Absorption
100%
Etimonis
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Etimonis
Patient Information
Etimonis
Organisms Affected
Humans and other mammals