Mononit Retard 50
Brand names,
Mononit Retard 50
Analogs
Mononit Retard 50
Brand Names Mixture
Mononit Retard 50
Chemical_Formula
C6H9NO6
Mononit Retard 50
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Mononit Retard 50
fda sheet
Mononit Retard 50
msds (material safety sheet)
Mononit Retard 50
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Mononit Retard 50
Molecular Weight
191.139 g/mol
Mononit Retard 50
Melting Point
88-91oC
Mononit Retard 50
H2O Solubility
1.07E+005 mg/L
Mononit Retard 50
State
Solid
Mononit Retard 50
LogP
-0.15
Mononit Retard 50
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Mononit Retard 50
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Mononit Retard 50
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mononit Retard 50
Absorption
100%
Mononit Retard 50
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Mononit Retard 50
Patient Information
Mononit Retard 50
Organisms Affected
Humans and other mammals