Imdur Durules
Brand names,
Imdur Durules
Analogs
Imdur Durules
Brand Names Mixture
Imdur Durules
Chemical_Formula
C6H9NO6
Imdur Durules
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Imdur Durules
fda sheet
Imdur Durules
msds (material safety sheet)
Imdur Durules
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Imdur Durules
Molecular Weight
191.139 g/mol
Imdur Durules
Melting Point
88-91oC
Imdur Durules
H2O Solubility
1.07E+005 mg/L
Imdur Durules
State
Solid
Imdur Durules
LogP
-0.15
Imdur Durules
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Imdur Durules
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Imdur Durules
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Imdur Durules
Absorption
100%
Imdur Durules
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Imdur Durules
Patient Information
Imdur Durules
Organisms Affected
Humans and other mammals