Edistol
Brand names,
Edistol
Analogs
Edistol
Brand Names Mixture
Edistol
Chemical_Formula
C6H9NO6
Edistol
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Edistol
fda sheet
Edistol
msds (material safety sheet)
Edistol
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Edistol
Molecular Weight
191.139 g/mol
Edistol
Melting Point
88-91oC
Edistol
H2O Solubility
1.07E+005 mg/L
Edistol
State
Solid
Edistol
LogP
-0.15
Edistol
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Edistol
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Edistol
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Edistol
Absorption
100%
Edistol
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Edistol
Patient Information
Edistol
Organisms Affected
Humans and other mammals