Vasdilat
Brand names,
Vasdilat
Analogs
Vasdilat
Brand Names Mixture
Vasdilat
Chemical_Formula
C6H9NO6
Vasdilat
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Vasdilat
fda sheet
Vasdilat
msds (material safety sheet)
Vasdilat
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Vasdilat
Molecular Weight
191.139 g/mol
Vasdilat
Melting Point
88-91oC
Vasdilat
H2O Solubility
1.07E+005 mg/L
Vasdilat
State
Solid
Vasdilat
LogP
-0.15
Vasdilat
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Vasdilat
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Vasdilat
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Vasdilat
Absorption
100%
Vasdilat
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Vasdilat
Patient Information
Vasdilat
Organisms Affected
Humans and other mammals