Ismox
Brand names,
Ismox
Analogs
Ismox
Brand Names Mixture
Ismox
Chemical_Formula
C6H9NO6
Ismox
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismox
fda sheet
Ismox
msds (material safety sheet)
Ismox
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismox
Molecular Weight
191.139 g/mol
Ismox
Melting Point
88-91oC
Ismox
H2O Solubility
1.07E+005 mg/L
Ismox
State
Solid
Ismox
LogP
-0.15
Ismox
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismox
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismox
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismox
Absorption
100%
Ismox
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismox
Patient Information
Ismox
Organisms Affected
Humans and other mammals