Ismn Heumann
Brand names,
Ismn Heumann
Analogs
Ismn Heumann
Brand Names Mixture
Ismn Heumann
Chemical_Formula
C6H9NO6
Ismn Heumann
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Heumann
fda sheet
Ismn Heumann
msds (material safety sheet)
Ismn Heumann
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Heumann
Molecular Weight
191.139 g/mol
Ismn Heumann
Melting Point
88-91oC
Ismn Heumann
H2O Solubility
1.07E+005 mg/L
Ismn Heumann
State
Solid
Ismn Heumann
LogP
-0.15
Ismn Heumann
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Heumann
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Heumann
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Heumann
Absorption
100%
Ismn Heumann
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Heumann
Patient Information
Ismn Heumann
Organisms Affected
Humans and other mammals