Monotrate
Brand names,
Monotrate
Analogs
Monotrate
Brand Names Mixture
Monotrate
Chemical_Formula
C6H9NO6
Monotrate
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monotrate
fda sheet
Monotrate
msds (material safety sheet)
Monotrate
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monotrate
Molecular Weight
191.139 g/mol
Monotrate
Melting Point
88-91oC
Monotrate
H2O Solubility
1.07E+005 mg/L
Monotrate
State
Solid
Monotrate
LogP
-0.15
Monotrate
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monotrate
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monotrate
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monotrate
Absorption
100%
Monotrate
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monotrate
Patient Information
Monotrate
Organisms Affected
Humans and other mammals