Monosorb
Brand names,
Monosorb
Analogs
Monosorb
Brand Names Mixture
Monosorb
Chemical_Formula
C6H9NO6
Monosorb
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monosorb
fda sheet
Monosorb
msds (material safety sheet)
Monosorb
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monosorb
Molecular Weight
191.139 g/mol
Monosorb
Melting Point
88-91oC
Monosorb
H2O Solubility
1.07E+005 mg/L
Monosorb
State
Solid
Monosorb
LogP
-0.15
Monosorb
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monosorb
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monosorb
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monosorb
Absorption
100%
Monosorb
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monosorb
Patient Information
Monosorb
Organisms Affected
Humans and other mammals