Monoket Od
Brand names,
Monoket Od
Analogs
Monoket Od
Brand Names Mixture
Monoket Od
Chemical_Formula
C6H9NO6
Monoket Od
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monoket Od
fda sheet
Monoket Od
msds (material safety sheet)
Monoket Od
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monoket Od
Molecular Weight
191.139 g/mol
Monoket Od
Melting Point
88-91oC
Monoket Od
H2O Solubility
1.07E+005 mg/L
Monoket Od
State
Solid
Monoket Od
LogP
-0.15
Monoket Od
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monoket Od
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monoket Od
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monoket Od
Absorption
100%
Monoket Od
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monoket Od
Patient Information
Monoket Od
Organisms Affected
Humans and other mammals