Mono Mack
Brand names,
Mono Mack
Analogs
Mono Mack
Brand Names Mixture
Mono Mack
Chemical_Formula
C6H9NO6
Mono Mack
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Mono Mack
fda sheet
Mono Mack
msds (material safety sheet)
Mono Mack
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Mono Mack
Molecular Weight
191.139 g/mol
Mono Mack
Melting Point
88-91oC
Mono Mack
H2O Solubility
1.07E+005 mg/L
Mono Mack
State
Solid
Mono Mack
LogP
-0.15
Mono Mack
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Mono Mack
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Mono Mack
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mono Mack
Absorption
100%
Mono Mack
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Mono Mack
Patient Information
Mono Mack
Organisms Affected
Humans and other mammals