Monosordil
Brand names,
Monosordil
Analogs
Monosordil
Brand Names Mixture
Monosordil
Chemical_Formula
C6H9NO6
Monosordil
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monosordil
fda sheet
Monosordil
msds (material safety sheet)
Monosordil
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monosordil
Molecular Weight
191.139 g/mol
Monosordil
Melting Point
88-91oC
Monosordil
H2O Solubility
1.07E+005 mg/L
Monosordil
State
Solid
Monosordil
LogP
-0.15
Monosordil
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monosordil
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monosordil
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monosordil
Absorption
100%
Monosordil
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monosordil
Patient Information
Monosordil
Organisms Affected
Humans and other mammals