Medocor
Brand names,
Medocor
Analogs
Medocor
Brand Names Mixture
Medocor
Chemical_Formula
C6H9NO6
Medocor
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Medocor
fda sheet
Medocor
msds (material safety sheet)
Medocor
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Medocor
Molecular Weight
191.139 g/mol
Medocor
Melting Point
88-91oC
Medocor
H2O Solubility
1.07E+005 mg/L
Medocor
State
Solid
Medocor
LogP
-0.15
Medocor
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Medocor
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Medocor
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Medocor
Absorption
100%
Medocor
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Medocor
Patient Information
Medocor
Organisms Affected
Humans and other mammals