Olicardin
Brand names,
Olicardin
Analogs
Olicardin
Brand Names Mixture
Olicardin
Chemical_Formula
C6H9NO6
Olicardin
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Olicardin
fda sheet
Olicardin
msds (material safety sheet)
Olicardin
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Olicardin
Molecular Weight
191.139 g/mol
Olicardin
Melting Point
88-91oC
Olicardin
H2O Solubility
1.07E+005 mg/L
Olicardin
State
Solid
Olicardin
LogP
-0.15
Olicardin
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Olicardin
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Olicardin
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Olicardin
Absorption
100%
Olicardin
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Olicardin
Patient Information
Olicardin
Organisms Affected
Humans and other mammals