Mono-Mack
Brand names,
Mono-Mack
Analogs
Mono-Mack
Brand Names Mixture
Mono-Mack
Chemical_Formula
C6H9NO6
Mono-Mack
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Mono-Mack
fda sheet
Mono-Mack
msds (material safety sheet)
Mono-Mack
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Mono-Mack
Molecular Weight
191.139 g/mol
Mono-Mack
Melting Point
88-91oC
Mono-Mack
H2O Solubility
1.07E+005 mg/L
Mono-Mack
State
Solid
Mono-Mack
LogP
-0.15
Mono-Mack
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Mono-Mack
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Mono-Mack
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mono-Mack
Absorption
100%
Mono-Mack
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Mono-Mack
Patient Information
Mono-Mack
Organisms Affected
Humans and other mammals