Ismn Stada
Brand names,
Ismn Stada
Analogs
Ismn Stada
Brand Names Mixture
Ismn Stada
Chemical_Formula
C6H9NO6
Ismn Stada
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Stada
fda sheet
Ismn Stada
msds (material safety sheet)
Ismn Stada
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Stada
Molecular Weight
191.139 g/mol
Ismn Stada
Melting Point
88-91oC
Ismn Stada
H2O Solubility
1.07E+005 mg/L
Ismn Stada
State
Solid
Ismn Stada
LogP
-0.15
Ismn Stada
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Stada
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Stada
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Stada
Absorption
100%
Ismn Stada
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Stada
Patient Information
Ismn Stada
Organisms Affected
Humans and other mammals