Monocedocard
Brand names,
Monocedocard
Analogs
Monocedocard
Brand Names Mixture
Monocedocard
Chemical_Formula
C6H9NO6
Monocedocard
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monocedocard
fda sheet
Monocedocard
msds (material safety sheet)
Monocedocard
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monocedocard
Molecular Weight
191.139 g/mol
Monocedocard
Melting Point
88-91oC
Monocedocard
H2O Solubility
1.07E+005 mg/L
Monocedocard
State
Solid
Monocedocard
LogP
-0.15
Monocedocard
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monocedocard
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monocedocard
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monocedocard
Absorption
100%
Monocedocard
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monocedocard
Patient Information
Monocedocard
Organisms Affected
Humans and other mammals