Percorina
Brand names,
Percorina
Analogs
Percorina
Brand Names Mixture
Percorina
Chemical_Formula
C6H9NO6
Percorina
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Percorina
fda sheet
Percorina
msds (material safety sheet)
Percorina
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Percorina
Molecular Weight
191.139 g/mol
Percorina
Melting Point
88-91oC
Percorina
H2O Solubility
1.07E+005 mg/L
Percorina
State
Solid
Percorina
LogP
-0.15
Percorina
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Percorina
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Percorina
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Percorina
Absorption
100%
Percorina
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Percorina
Patient Information
Percorina
Organisms Affected
Humans and other mammals