Isomon
Brand names,
Isomon
Analogs
Isomon
Brand Names Mixture
Isomon
Chemical_Formula
C6H9NO6
Isomon
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Isomon
fda sheet
Isomon
msds (material safety sheet)
Isomon
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Isomon
Molecular Weight
191.139 g/mol
Isomon
Melting Point
88-91oC
Isomon
H2O Solubility
1.07E+005 mg/L
Isomon
State
Solid
Isomon
LogP
-0.15
Isomon
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Isomon
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Isomon
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Isomon
Absorption
100%
Isomon
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Isomon
Patient Information
Isomon
Organisms Affected
Humans and other mammals