Ismn Abz
Brand names,
Ismn Abz
Analogs
Ismn Abz
Brand Names Mixture
Ismn Abz
Chemical_Formula
C6H9NO6
Ismn Abz
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Abz
fda sheet
Ismn Abz
msds (material safety sheet)
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Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Abz
Molecular Weight
191.139 g/mol
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Melting Point
88-91oC
Ismn Abz
H2O Solubility
1.07E+005 mg/L
Ismn Abz
State
Solid
Ismn Abz
LogP
-0.15
Ismn Abz
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Abz
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Abz
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Abz
Absorption
100%
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side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Abz
Patient Information
Ismn Abz
Organisms Affected
Humans and other mammals