Elantan Retard
Brand names,
Elantan Retard
Analogs
Elantan Retard
Brand Names Mixture
Elantan Retard
Chemical_Formula
C6H9NO6
Elantan Retard
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Elantan Retard
fda sheet
Elantan Retard
msds (material safety sheet)
Elantan Retard
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Elantan Retard
Molecular Weight
191.139 g/mol
Elantan Retard
Melting Point
88-91oC
Elantan Retard
H2O Solubility
1.07E+005 mg/L
Elantan Retard
State
Solid
Elantan Retard
LogP
-0.15
Elantan Retard
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Elantan Retard
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Elantan Retard
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Elantan Retard
Absorption
100%
Elantan Retard
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Elantan Retard
Patient Information
Elantan Retard
Organisms Affected
Humans and other mammals