Monosigma
Brand names,
Monosigma
Analogs
Monosigma
Brand Names Mixture
Monosigma
Chemical_Formula
C6H9NO6
Monosigma
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monosigma
fda sheet
Monosigma
msds (material safety sheet)
Monosigma
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monosigma
Molecular Weight
191.139 g/mol
Monosigma
Melting Point
88-91oC
Monosigma
H2O Solubility
1.07E+005 mg/L
Monosigma
State
Solid
Monosigma
LogP
-0.15
Monosigma
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monosigma
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monosigma
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monosigma
Absorption
100%
Monosigma
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monosigma
Patient Information
Monosigma
Organisms Affected
Humans and other mammals