Monoclair
Brand names,
Monoclair
Analogs
Monoclair
Brand Names Mixture
Monoclair
Chemical_Formula
C6H9NO6
Monoclair
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monoclair
fda sheet
Monoclair
msds (material safety sheet)
Monoclair
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monoclair
Molecular Weight
191.139 g/mol
Monoclair
Melting Point
88-91oC
Monoclair
H2O Solubility
1.07E+005 mg/L
Monoclair
State
Solid
Monoclair
LogP
-0.15
Monoclair
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monoclair
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monoclair
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monoclair
Absorption
100%
Monoclair
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monoclair
Patient Information
Monoclair
Organisms Affected
Humans and other mammals