Conpin Retardkaps
Brand names,
Conpin Retardkaps
Analogs
Conpin Retardkaps
Brand Names Mixture
Conpin Retardkaps
Chemical_Formula
C6H9NO6
Conpin Retardkaps
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Conpin Retardkaps
fda sheet
Conpin Retardkaps
msds (material safety sheet)
Conpin Retardkaps
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Conpin Retardkaps
Molecular Weight
191.139 g/mol
Conpin Retardkaps
Melting Point
88-91oC
Conpin Retardkaps
H2O Solubility
1.07E+005 mg/L
Conpin Retardkaps
State
Solid
Conpin Retardkaps
LogP
-0.15
Conpin Retardkaps
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Conpin Retardkaps
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Conpin Retardkaps
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Conpin Retardkaps
Absorption
100%
Conpin Retardkaps
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Conpin Retardkaps
Patient Information
Conpin Retardkaps
Organisms Affected
Humans and other mammals