Monodur Durules
Brand names,
Monodur Durules
Analogs
Monodur Durules
Brand Names Mixture
Monodur Durules
Chemical_Formula
C6H9NO6
Monodur Durules
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monodur Durules
fda sheet
Monodur Durules
msds (material safety sheet)
Monodur Durules
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monodur Durules
Molecular Weight
191.139 g/mol
Monodur Durules
Melting Point
88-91oC
Monodur Durules
H2O Solubility
1.07E+005 mg/L
Monodur Durules
State
Solid
Monodur Durules
LogP
-0.15
Monodur Durules
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monodur Durules
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monodur Durules
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monodur Durules
Absorption
100%
Monodur Durules
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monodur Durules
Patient Information
Monodur Durules
Organisms Affected
Humans and other mammals