Monisid
Brand names,
Monisid
Analogs
Monisid
Brand Names Mixture
Monisid
Chemical_Formula
C6H9NO6
Monisid
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
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fda sheet
Monisid
msds (material safety sheet)
Monisid
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monisid
Molecular Weight
191.139 g/mol
Monisid
Melting Point
88-91oC
Monisid
H2O Solubility
1.07E+005 mg/L
Monisid
State
Solid
Monisid
LogP
-0.15
Monisid
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monisid
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monisid
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monisid
Absorption
100%
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side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monisid
Patient Information
Monisid
Organisms Affected
Humans and other mammals