Ismn Apogepha
Brand names,
Ismn Apogepha
Analogs
Ismn Apogepha
Brand Names Mixture
Ismn Apogepha
Chemical_Formula
C6H9NO6
Ismn Apogepha
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Apogepha
fda sheet
Ismn Apogepha
msds (material safety sheet)
Ismn Apogepha
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Apogepha
Molecular Weight
191.139 g/mol
Ismn Apogepha
Melting Point
88-91oC
Ismn Apogepha
H2O Solubility
1.07E+005 mg/L
Ismn Apogepha
State
Solid
Ismn Apogepha
LogP
-0.15
Ismn Apogepha
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Apogepha
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Apogepha
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Apogepha
Absorption
100%
Ismn Apogepha
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Apogepha
Patient Information
Ismn Apogepha
Organisms Affected
Humans and other mammals