Monit
Brand names,
Monit
Analogs
Monit
Brand Names Mixture
Monit
Chemical_Formula
C6H9NO6
Monit
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monit
fda sheet
Monit
msds (material safety sheet)
Monit
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monit
Molecular Weight
191.139 g/mol
Monit
Melting Point
88-91oC
Monit
H2O Solubility
1.07E+005 mg/L
Monit
State
Solid
Monit
LogP
-0.15
Monit
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monit
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monit
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monit
Absorption
100%
Monit
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monit
Patient Information
Monit
Organisms Affected
Humans and other mammals