Vasotrate
Brand names,
Vasotrate
Analogs
Vasotrate
Brand Names Mixture
Vasotrate
Chemical_Formula
C6H9NO6
Vasotrate
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Vasotrate
fda sheet
Vasotrate
msds (material safety sheet)
Vasotrate
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Vasotrate
Molecular Weight
191.139 g/mol
Vasotrate
Melting Point
88-91oC
Vasotrate
H2O Solubility
1.07E+005 mg/L
Vasotrate
State
Solid
Vasotrate
LogP
-0.15
Vasotrate
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Vasotrate
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Vasotrate
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Vasotrate
Absorption
100%
Vasotrate
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Vasotrate
Patient Information
Vasotrate
Organisms Affected
Humans and other mammals