Imdur
Brand names,
Imdur
Analogs
Imdur
Brand Names Mixture
Imdur
Chemical_Formula
C6H9NO6
Imdur
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Imdur
fda sheet
Imdur
msds (material safety sheet)
Imdur
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Imdur
Molecular Weight
191.139 g/mol
Imdur
Melting Point
88-91oC
Imdur
H2O Solubility
1.07E+005 mg/L
Imdur
State
Solid
Imdur
LogP
-0.15
Imdur
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Imdur
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Imdur
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Imdur
Absorption
100%
Imdur
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Imdur
Patient Information
Imdur
Organisms Affected
Humans and other mammals