Monosorbitrate
Brand names,
Monosorbitrate
Analogs
Monosorbitrate
Brand Names Mixture
Monosorbitrate
Chemical_Formula
C6H9NO6
Monosorbitrate
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Monosorbitrate
fda sheet
Monosorbitrate
msds (material safety sheet)
Monosorbitrate
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Monosorbitrate
Molecular Weight
191.139 g/mol
Monosorbitrate
Melting Point
88-91oC
Monosorbitrate
H2O Solubility
1.07E+005 mg/L
Monosorbitrate
State
Solid
Monosorbitrate
LogP
-0.15
Monosorbitrate
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Monosorbitrate
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Monosorbitrate
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Monosorbitrate
Absorption
100%
Monosorbitrate
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Monosorbitrate
Patient Information
Monosorbitrate
Organisms Affected
Humans and other mammals