Conpin
Brand names,
Conpin
Analogs
Conpin
Brand Names Mixture
Conpin
Chemical_Formula
C6H9NO6
Conpin
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Conpin
fda sheet
Conpin
msds (material safety sheet)
Conpin
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Conpin
Molecular Weight
191.139 g/mol
Conpin
Melting Point
88-91oC
Conpin
H2O Solubility
1.07E+005 mg/L
Conpin
State
Solid
Conpin
LogP
-0.15
Conpin
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Conpin
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Conpin
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Conpin
Absorption
100%
Conpin
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Conpin
Patient Information
Conpin
Organisms Affected
Humans and other mammals