Iturol
Brand names,
Iturol
Analogs
Iturol
Brand Names Mixture
Iturol
Chemical_Formula
C6H9NO6
Iturol
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Iturol
fda sheet
Iturol
msds (material safety sheet)
Iturol
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Iturol
Molecular Weight
191.139 g/mol
Iturol
Melting Point
88-91oC
Iturol
H2O Solubility
1.07E+005 mg/L
Iturol
State
Solid
Iturol
LogP
-0.15
Iturol
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Iturol
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Iturol
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Iturol
Absorption
100%
Iturol
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Iturol
Patient Information
Iturol
Organisms Affected
Humans and other mammals