Ismn Lannacher
Brand names,
Ismn Lannacher
Analogs
Ismn Lannacher
Brand Names Mixture
Ismn Lannacher
Chemical_Formula
C6H9NO6
Ismn Lannacher
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Lannacher
fda sheet
Ismn Lannacher
msds (material safety sheet)
Ismn Lannacher
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Lannacher
Molecular Weight
191.139 g/mol
Ismn Lannacher
Melting Point
88-91oC
Ismn Lannacher
H2O Solubility
1.07E+005 mg/L
Ismn Lannacher
State
Solid
Ismn Lannacher
LogP
-0.15
Ismn Lannacher
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Lannacher
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Lannacher
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Lannacher
Absorption
100%
Ismn Lannacher
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Lannacher
Patient Information
Ismn Lannacher
Organisms Affected
Humans and other mammals