Ismn Hexal
Brand names,
Ismn Hexal
Analogs
Ismn Hexal
Brand Names Mixture
Ismn Hexal
Chemical_Formula
C6H9NO6
Ismn Hexal
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Ismn Hexal
fda sheet
Ismn Hexal
msds (material safety sheet)
Ismn Hexal
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Ismn Hexal
Molecular Weight
191.139 g/mol
Ismn Hexal
Melting Point
88-91oC
Ismn Hexal
H2O Solubility
1.07E+005 mg/L
Ismn Hexal
State
Solid
Ismn Hexal
LogP
-0.15
Ismn Hexal
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Ismn Hexal
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Ismn Hexal
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Ismn Hexal
Absorption
100%
Ismn Hexal
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Ismn Hexal
Patient Information
Ismn Hexal
Organisms Affected
Humans and other mammals