Imdur 60
Brand names,
Imdur 60
Analogs
Imdur 60
Brand Names Mixture
Imdur 60
Chemical_Formula
C6H9NO6
Imdur 60
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Imdur 60
fda sheet
Imdur 60
msds (material safety sheet)
Imdur 60
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Imdur 60
Molecular Weight
191.139 g/mol
Imdur 60
Melting Point
88-91oC
Imdur 60
H2O Solubility
1.07E+005 mg/L
Imdur 60
State
Solid
Imdur 60
LogP
-0.15
Imdur 60
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Imdur 60
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Imdur 60
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Imdur 60
Absorption
100%
Imdur 60
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Imdur 60
Patient Information
Imdur 60
Organisms Affected
Humans and other mammals