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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C6H9NO6
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RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
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Molecular Weight
191.139 g/mol
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Melting Point
88-91oC
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H2O Solubility
1.07E+005 mg/L
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State
Solid
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LogP
-0.15
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Dosage Forms
Tablet (immediate release); Tablet (extended release)
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Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
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Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
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Absorption
100%
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side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
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Patient Information
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Organisms Affected
Humans and other mammals