Duride
Brand names,
Duride
Analogs
Duride
Brand Names Mixture
Duride
Chemical_Formula
C6H9NO6
Duride
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Duride
fda sheet
Duride
msds (material safety sheet)
Duride
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Duride
Molecular Weight
191.139 g/mol
Duride
Melting Point
88-91oC
Duride
H2O Solubility
1.07E+005 mg/L
Duride
State
Solid
Duride
LogP
-0.15
Duride
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Duride
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Duride
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Duride
Absorption
100%
Duride
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Duride
Patient Information
Duride
Organisms Affected
Humans and other mammals