Nitramin
Brand names,
Nitramin
Analogs
Nitramin
Brand Names Mixture
Nitramin
Chemical_Formula
C6H9NO6
Nitramin
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Nitramin
fda sheet
Nitramin
msds (material safety sheet)
Nitramin
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Nitramin
Molecular Weight
191.139 g/mol
Nitramin
Melting Point
88-91oC
Nitramin
H2O Solubility
1.07E+005 mg/L
Nitramin
State
Solid
Nitramin
LogP
-0.15
Nitramin
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Nitramin
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Nitramin
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Nitramin
Absorption
100%
Nitramin
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Nitramin
Patient Information
Nitramin
Organisms Affected
Humans and other mammals