Sigacora
Brand names,
Sigacora
Analogs
Sigacora
Brand Names Mixture
Sigacora
Chemical_Formula
C6H9NO6
Sigacora
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Sigacora
fda sheet
Sigacora
msds (material safety sheet)
Sigacora
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Sigacora
Molecular Weight
191.139 g/mol
Sigacora
Melting Point
88-91oC
Sigacora
H2O Solubility
1.07E+005 mg/L
Sigacora
State
Solid
Sigacora
LogP
-0.15
Sigacora
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Sigacora
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Sigacora
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Sigacora
Absorption
100%
Sigacora
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Sigacora
Patient Information
Sigacora
Organisms Affected
Humans and other mammals