Plodin
Brand names,
Plodin
Analogs
Plodin
Brand Names Mixture
Plodin
Chemical_Formula
C6H9NO6
Plodin
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Plodin
fda sheet
Plodin
msds (material safety sheet)
Plodin
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Plodin
Molecular Weight
191.139 g/mol
Plodin
Melting Point
88-91oC
Plodin
H2O Solubility
1.07E+005 mg/L
Plodin
State
Solid
Plodin
LogP
-0.15
Plodin
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Plodin
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Plodin
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Plodin
Absorption
100%
Plodin
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Plodin
Patient Information
Plodin
Organisms Affected
Humans and other mammals