Fem-Mono
Brand names,
Fem-Mono
Analogs
Fem-Mono
Brand Names Mixture
Fem-Mono
Chemical_Formula
C6H9NO6
Fem-Mono
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Fem-Mono
fda sheet
Fem-Mono
msds (material safety sheet)
Fem-Mono
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Fem-Mono
Molecular Weight
191.139 g/mol
Fem-Mono
Melting Point
88-91oC
Fem-Mono
H2O Solubility
1.07E+005 mg/L
Fem-Mono
State
Solid
Fem-Mono
LogP
-0.15
Fem-Mono
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Fem-Mono
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Fem-Mono
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Fem-Mono
Absorption
100%
Fem-Mono
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Fem-Mono
Patient Information
Fem-Mono
Organisms Affected
Humans and other mammals