Sorbimon
Brand names,
Sorbimon
Analogs
Sorbimon
Brand Names Mixture
Sorbimon
Chemical_Formula
C6H9NO6
Sorbimon
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Sorbimon
fda sheet
Sorbimon
msds (material safety sheet)
Sorbimon
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Sorbimon
Molecular Weight
191.139 g/mol
Sorbimon
Melting Point
88-91oC
Sorbimon
H2O Solubility
1.07E+005 mg/L
Sorbimon
State
Solid
Sorbimon
LogP
-0.15
Sorbimon
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Sorbimon
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Sorbimon
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Sorbimon
Absorption
100%
Sorbimon
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Sorbimon
Patient Information
Sorbimon
Organisms Affected
Humans and other mammals