Mononit 40
Brand names,
Mononit 40
Analogs
Mononit 40
Brand Names Mixture
Mononit 40
Chemical_Formula
C6H9NO6
Mononit 40
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Mononit 40
fda sheet
Mononit 40
msds (material safety sheet)
Mononit 40
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Mononit 40
Molecular Weight
191.139 g/mol
Mononit 40
Melting Point
88-91oC
Mononit 40
H2O Solubility
1.07E+005 mg/L
Mononit 40
State
Solid
Mononit 40
LogP
-0.15
Mononit 40
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Mononit 40
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Mononit 40
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Mononit 40
Absorption
100%
Mononit 40
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Mononit 40
Patient Information
Mononit 40
Organisms Affected
Humans and other mammals